Van de Ven Double Ends The Toffees' Run at Brand New Home Ground
Micky van de Ven became the first defender to net twice in a English top-flight game for Spurs since Jan Vertonghen in spring 2013.
Key points
The Spurs defender heads home twice in first half
The home side's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr scores third in dying moments
This loss is Everton's initial at their new ground
The Tottenham defender found the net on two occasions as Tottenham extended their winning streak on the road in the Premier League and delivered the Toffees their first defeat at their new home.
The Toffees were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the first half to put their strong form at jeopardy, and they were failed to mount a comeback before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a final goal to seal the victory.
The Everton defender believed he had levelled the tally five minutes after the defender's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, missed a number of chances, while Vicario made a series of excellent saves to ensure the London club went five away games unbeaten in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to check the goal on the screen and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates the manager's side up to third in the division, five points off north London rivals and leaders Arsenal.
The Merseyside club remain 14th and are half a dozen points clear of the drop zone.
Spurs breakdown: The defender excels in duties at both ends of the field
Following a uninspiring weekday display in the European competition against the French side, where they managed a only attempts on goal, the manager chose the French striker up front instead of former Toffees player Richarlison.
The summer signing was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an attacking force to be reckoned with.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an free the defender to score.
And the captain - filling in as skipper in Cristian Romero's absence - added his next goal in added time as he rose above Jordan Pickford to nod in.
The Dutchman was just as outstanding in defensive duties, partnering effectively with Kevin Danso as the duo handled excellently with the 34 crosses thrown their way by Everton.
Toffees breakdown: Everton lacking finishing touch
The club's new home had been a happy hunting ground, but it seems the novelty may have worn off somewhat and supporters flocked to the gates after the midfielder's final goal for Spurs.
The end in Everton's unbeaten home run will not be a massive worry for the manager, but their attacking woes are.
The forward and the other striker - the Everton's pair of recognised strikers - had scored just a single goal between them before Sunday's outing.
And they were failed to add to that poor record on a wet and gloomy night on in Liverpool.
The striker's form was epitomized when he opted to overhead kick a golden opportunity from near the goal, despite having room and opportunity to readjust for a more conventional attempt that would have tested Vicario.
The substitute, as well, failed to make an impact after replacing Beto in the second half.
It wasn't for a lack of chance. The majority of Everton's attacks came through the winger and the forward, who relentlessly whipped threatening balls into the Spurs penalty area.
What next for these two sides?
Everton: The team head to Sunderland in the Premier League on early November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup match against Newcastle.